Abstrait

The correlation between levels of Immunoglobulin M (IgM) specific rubella with examination result of brainstem evoked response audiometry on congenital rubella syndrome patients.

Yudistira D*, Rianto BUD, Prasetyo A

Background: Congenital Rubella Syndrome is a disease caused by infection with rubella or German measles virus. The clinical symptoms are not typical rubella infection and diagnosis with clinical symptoms is inaccurate. Investigations to determine levels of antibody (IgG and IgM) against rubella play an important role in the diagnosis of rubella. One of the clinical manifestations of CRS is hearing loss. Investigations are good enough to detect hearing loss is Brainstem Auditory Evoked Response (BERA). The aim of this study is analyze the correlation levels of immunoglobulin M (IgM) with threshold hearing on Congenital Rubella Syndrome patients in the Dr. Sardjito Hospital. Method: Study is a cross sectional study on the correlation of the levels of immunoglobulin M in patients with Congenital Rubella Syndrome BERA examination results in patients with Congenital Rubella Syndrome. Inclusion criteria are children diagnosed with congenital rubella syndrome. Subject is less than 24 month of age. Hearing impairment by BERA analysis. Serology tested for rubella specific immunoglobulin. Exclusion criteria are subjects with incomplete medical records. Results: The samples were 47 patients with IgM Positive, Imunoglobulin M and BERA were examined and the result of correlation between immunoglobulin M and BERA result with p value 0.001 with correlation coefficient 0.606. Conclusion: There is a positive correlation between specific rubella immunoglobulin M (IgM) level and BERA test results, the higher the specific rubella immunoglobulin M (IgM) level, the greater the hearing loss.