Abstrait

Study on predictive function of TEG on blood coagulation changes in patients with cerebral traumatic hemorrhage

Lin Lu, Dongseng Zhang, Xianghua Li, Yongqiu Li

Objective: To analyse predictive function of TEG on blood coagulation changes in patients with cerebral traumatic hemorrhage.

Methods: Fifty-four patients with traumatic hemorrhage in ICU of our hospital from August, 2013 to October, 2014 were recruited, which included 42 patients with cerebral traumatic hemorrhage and 12 with other types of traumatic hemorrhage, all patients were given TEG in 1 d, 2 d, 7 d after trauma, and blood coagulation parameter of R value, K value, α value and Ma value were monitored, the regularity at time points were analysed.

Results: Blood coagulation parameters of recruited patients in each group were compared, there were significant statistical differences in K value, α value and Ma (P<0.05 whereas R value did not show significant differences (P>0.05). However, the difference between different time points of the same group was significant (P<0.05). There was interaction function between them (P<0.05). Compared with patients with other kinds of traumatic hemorrhage, changes of R value and K value in patients with cerebral traumatic hemorrhage were lowest in 1 d after trauma (P<0.05), but highest in 3 d after trauma (P<0.05), there were no statistical differences in 7 d after trauma between two groups (P>0.05). Changes of α value and Ma value were highest in 1 d after trauma (P<0.05), lowest in 3 d after trauma (P<0.05), and there were no significant statistical differences in 7 d after trauma (P>0.05).

Conclusion: Patients with cerebral traumatic hemorrhage have certain differences with patients with other kinds of traumatic hemorrhage in blood coagulation. The former is more severe. And its coagulation function changes have certain regularity. In 1 d after trauma, there is hypercoagulability. In 3 d after trauma, there is hypocoagulability. In 7 d after trauma, all blood coagulation functions are normal.