Abstrait

How many mcr-1-harbouring bacteria were spreading geographically?

Kwang Seung Park, Jung Hun Lee, Moonhee Park, Kwan Soo Ko, Sang Hee Lee

Colistin is widely used as an antibiotic of last resort for treating infections caused by multidrug-resistant gram-negative bacteria such as carbapenemase-producing Enterobacteriaceae. Recently, the emergence of plasmid-mediated (horizontally-transferable) colistin resistance (mcr-1) has become a great challenge to global public health. The mcr-1 gene was detected in ESBL (Extended Spectrum β-Lactamase)- producing and/or carbapenemase-producing Enterobacteriaceae. Therefore, there is a huge risk of the emergence of pan-drug-resistant gram-negative bacteria. In this paper we discuss the epidemiological analyses of mcr-1 positive Enterobacteriaceae and structural analyses of PmrC that was recently identified as a protein associated with colistin resistance.