Abstrait

A study on the effect of ion chelating agent on Alzheimer disease

Yan Zhao, Peng Sun, Bing Chen, Peng Lun, Yihe Dou, Wei Wei Cao

Background: A new type of treatment is still needed for sporadic Alzheimer disease. The ion chelating agent (such as M30 and HLA-20) and other kinds of ion chelating agent possess brain tissue permeability. At present, the study has confirmed that ion chelating agent possesses a certain neuroprotective effect on neural degenerative disease. The objective of this study is to explore the related mechanism of ion chelating agent by applying the rat model of Alzheimer disease.

Methods: Injected STZ into the encephalocoele to make rat AD model and took M30, HLA20 ion chelating agent orally. Then we evaluated the function of ion chelating agent by water maze test, passive avoidance test and other behavioral tests.

Results: Compared with the rats in simple AD group, the spatial memory impairment of the rats in chelating agent group was reduced. Taking chelating agent orally for 11 w could make the rats with formed memory damage return to normal level in passive avoidance test. Long-term treatment could recover STZ induced high phosphorus acidification and the expression level of insulin degrading enzyme in hippocampal area.

Conclusion: Ion chelating agent possesses obvious therapeutic effect of nerve protection in STZ induced AD rat model.