Journal de toxicologie clinique et expérimentale


Study the Designment of Drugs that simultaneously target viral and human helicases

Aigerim Kassym

 Hepatocellular carcinoma (HCC) is the most prevalent type of primary liver cancer and the second leading cause of cancer death globally. The principal risk factor for HCC is chronic infection with hepatitis C or B virus. Although direct-acting antivirals are effective in reducing viral load in chronic hepatitis, HCV-infected patients still remain at risk of developing HCC. Therefore, new therapeutic strategies need to be developed for this detrimental condition. Recently, it was found that Ruvbl2, an ATP-dependent DNA helicase, is overexpressed in HCC and is associated with poor prognosis. On the other hand, HCV also utilizes a helicase, NS3, to replicate its genome. These human and viral helicases share evolutionarily conserved motifs that are involved in important functions of the enzyme. Here, we propose simultaneous targeting of HCV helicase NS3 and human helicase Ruvbl2 in the liver for, respectively, treating HCV infection and preventing HCC.


Hepatocellular carcinoma (HCC) is the most widely recognized essential liver problem and is a main source of malignancy related passing around the world. In the United States, HCC is the ninth driving reason for disease passings. Notwithstanding progresses in anticipation methods, screening, and new advancements in both analysis and treatment, rate and mortality keep on rising. Cirrhosis remains the most significant hazard factor for the improvement of HCC paying little heed to etiology. Hepatitis B and C are free hazard factors for the improvement of cirrhosis. Liquor utilization stays a significant extra hazard factor in the United States as liquor misuse is multiple times higher than hepatitis C. Finding is affirmed without pathologic affirmation. Screening incorporates both radiologic tests, for example, ultrasound, electronic tomography, and attractive reverberation imaging, and serological markers, for example, α-fetoprotein at half year spans. Numerous treatment modalities exist; be that as it may, just orthotopic liver transplantation (OLT) or careful resection is corrective. OLT is accessible for patients who meet or are downstaged into the Milan or University of San Francisco standards. Extra treatment modalities incorporate transarterial chemoembolization, radiofrequency removal, microwave removal, percutaneous ethanol infusion, cryoablation, radiation treatment, fundamental chemotherapy, and molecularly focused on treatments. Choice of a treatment methodology depends on tumor size, area, extrahepatic spread, and basic liver capacity.