Abstrait

Mito depressive effect and chromosomal aberrations induced by KBrO3 on A. sativum L root tips.

Hoda A Khatab, Samia Eissa Nagat, S Elhaddad

The present study was conducted to evaluate the potential cytotoxicity and genotoxicity of different treatments potassium bromate (KBrO3) using Allium sativum bio assay. The roots of A. sativum were treated with the concentration of 3 g/L, 5 g/L, 7 g/L and 9 g/L of KBrO3 for 2 hour, 6 hour and 24 hour treatment incubation times. Our results show that KBrO3 significantly inhibited the Mitotic Index (MI) compared to the control in a time and concentration-dependent manner. The decreasing of the mitotic index was dependent on the concentration and incubation time of treatment. KBrO3 slightly increased the percentage of abnormal cells. The present study indicates that extensive use of food additive should be assessed because of genotoxic and cytotoxic impacts on public health. Thus,continued efforts are needed to judge potential toxic effects of these chemicals on other living systems like human to ensure the survival of all forms of life.