Abstrait

Kidney-derived proteins and chronic kidney disease

James Wurdack

Because chronic kidney disease (CKD) has few objective signs, it is difficult to diagnose it early with existing methods. As a result, new biomarkers for the early diagnosis of renal failure are required. We focused our search for new CKD biomarkers on kidney-derived proteins that could correctly reflect the organ's disease state. To uncover putative marker proteins, we used a proteomics analysis on renal inflow and efflux blood from the same person. Proteomics research was used to discover proteins in the incoming blood. Because the plasma C1q level was significantly elevated in the renal efflux of donors, we chose complement C1q as a candidate from among the identified proteins. Furthermore, the plasma concentration of C1q increased significantly in a mouse model of diabetic nephropathy in concert with increases in blood glucose and urine protein content. We also discovered that a rise in C1q in CKD patients' plasma was linked to a drop in their estimated glomerular filtration rate. Overall, our findings imply that concentrating on kidney-derived proteins is a promising technique for discovering new CKD biomarkers, and that C1q has the potential to be a renal function biomarker.