Abstrait

Initial serum level of IL-10 as an outcome predictor in children with sepsis

Idham Jaya Ganda*, Milda, Sitti Aizah Lawang, Dasril Daud

Objective: Sepsis is the leading causes of morbidity and mortality in critically patients in many intensive care units. IL-10 was the major circulating antiinflamatory cytokine that has a role in the pathogenesis of sepsis and septic shock. The aim of this study is to determine the role of IL-10 as an outcome predictor in pediatric sepsis patient. Methods: A total of 70 sepsis patients were included in this study. Plasma specimens were collected at admission, then the patients were followed until the patients get shock or not. The diagnosis of sepsis is IDAI 2016 criteria. Serum IL-10 was measured using Enzyme Linked Immunosorbent Assay technique. Results: The initial serum levels of IL-10 was significantly decreased in both groups, but lower in the septic shock group. Cut of point <255 pg/ml was obtained through the ROC, with the sensitivity 100%, spesificity 100%, positive predictive value 100%, negative predictive value 100% Conclusions: The initial serum level of IL-10 can be used as an outcome predictor in pediatric sepsis patient and the limit of level <255 pg/ml is the most optimal cut off point as a prognostic value.