Abstrait

Extraintestinal manifestations of inflammatory bowel disease: Clinical aspects and pathogenesis.

Sandro da Costa Ferreira*, Bernardo Bezerra Martins de Oliveira, André Marussi Morsoletto, Ana de Lourdes Candolo Martinelli, Luiz Ernesto de Almeida Troncon

Background: Extraintestinal manifestations (EIM) are common in patients with inflammatory bowel disease (IBD). These manifestations can affect many organs, and joints, skin, eyes and hepatobiliary tract the most commonly affected sites. Among patients with IBD about 36% of them will have at least one EIM lifelong. Perianal Crohn’s disease, colonic involvement and smoking are associated with susceptibility to the development of EIM. Objective: This article reviewed the clinical aspects and the pathogenesis of main extraintestinal manifestations in IBD. Methods: Bibliographical searches were performed in PubMed (January 1990–October 2017), using specific terms. Conclusion: It is believed that the diseased gastrointestinal mucosa can trigger immune responses in extraintestinal sites due to shared epitopes in genetically susceptible individuals, although its pathogenesis is not fully understood.