Abstrait

Evaluation methods and polymers used in gastroretentive dosage forms: A recent update.

Anjana MN*, A Pasupathi

Recently in the field of oral drug delivery, the Gastro retentive Drug Delivery system (GRDDS) has gained immense popularity. By this systems dosage form retain in the stomach for an extended period of time and release the drug slowly that can challenge may disadvantages associated with conventional oral delivery, including poor bioavailability. Such dosage forms aim to release drugs in the upper part of the gastro intestinal tract especially in the stomach in a controlled release manner that might provide sustained release characteristics without sacrificing much of total bioavailability. Apart from in vitro characterisation, successful GRDDS development demands well designed in vivo study to establish enhanced gastro retention and prolonged drug release. Gama scintigraphy and MRI are popular techniques used to evaluate in vivo gastric residence time. The floating drug delivery systems are required to possess proper floating capability in gastric systems and use of natural polymers in such delivery system has been very beneficial. Natural gums are among the most popular hydrophilic polymers be because of cost-effectiveness and regulatory acceptance. Natural polymers have no of advantages like nontoxic, biocompatible, natural in origin. This review also gives a brief idea about advanced polymers including Eudragit, Carbopol, Hydroxyl Propyl Methyl Cellulose etc. and other excipients used for formulating GRDDS. This review also highlights the different parameters of GRDDS.