Abstrait

Epidemilology of shigella infection and evaluation of metabolic activity

Daniel Victor

Diarrhoea is a major global health problem, and recent studies have identified Shigella as a major contributor to this burden. Here we review recent advances in Shigella research. We focus on their epidemiology, etiology, antimicrobial resistance, and the role of the gut microbiota during infection. A combination of improved epidemiological data and a new generation of diagnostics have revealed that the Shigella burden is greater than previously thought. This is not limited to vulnerable populations in low- and middle-income countries. As we gain more and more detailed insight into the orchestrated mechanisms utilized by Shigella to induce infections, we can also begin to understand the complex role of the gut micro biota in preventing and inducing such infections. Using genomics in combination with epidemiological data and laboratory studies has elucidated the evolution and distribution of different species.