Abstrait

Effect of corticosteroids cortisol hormone [hydrocortisone] on the of the blood parameter in pregnant and non-pregnant laboratory females mice.

Al-Maliki SJ, Al-Ali AA, Kathim AS

The present study aimed to identify the effect of hydrocortisone on blood parameters in mice (Mus musculus). Adult female mice (n=144 mice) divided into two groups control group (CO group and treatment group T group per group (n=72 mice). Co group were injected with normal saline, whereas, T group i.p was injected with (0.21 mg/kg of body weight) hydrocortisone respectively for 10 days. Post completed 10 days, 6 females from per groups were taken and subjected for the purpose of studying the effect of the hormone on non-pregnant mice, and the remaining female mice were matched for the purpose of studying the effect of the hormone on female pregnant and dissected after 9 days of mating until 19 days. The hormone showed a significant increase in the number of white blood cells (WBC) count in non-pregnant female mice and Monocytes in female rats after 9 days of mating. The significant decrease in the number of granular cells in female rats after 10 and 15, 19 days of mating. The hormone showed a significant increase in the amount of hemoglobin in pregnant and non-pregnant female mice and red blood cells in pregnant females only.