Journal de toxicologie clinique et expérimentale


Differential effect of iodine bioorganic molecular complex on host defense in c57bl/6 mice

Tamara Bukeyeva

Long involvement with the utilization of different iodine arrangements has demonstrated that while having articulated antibacterial and antiviral properties, wide-range antimicrobial movement, and lacking mutagenic and teratogenic impacts, they are harmful when acquainted with the human body, which altogether limits the extent of their clinical application. The quest for elective approaches to take care of the issue of high harmfulness of inorganic iodine mixes has prompted the improvement of iodine-containing natural buildings. Iodine is described by a high bioactivity and applies wide antimicrobial range with no recorder confirmations of opposition advancement to iodine in microscopic organisms and infections. The new enemy of irresistible medication (FS-1) containing sub-atomic iodine has been as of late made.    

They are active ingredients of mixtures that in aqueous solutions consist of molecular iodine, bio-organic ligands, and potassium and lithium halo genides. In these drugs molecular iodine is in such an active form that after oral administration it minimizes toxic effects in humans. Previously it was shown that the active complex (AC) of the drugs contains molecular iodine that is located inside α-helix of dextrin and is coordinated by lithium halides and polypeptides (LiI5-α-dextrin polypeptide). In these types of complexes the electronic structure of the I2 molecule is different from the electronic structure of I2 in complexes with organic ligands, or in its free state. Interestingly, in the AC the molecular iodine exhibits acceptor properties with respect to polypeptides, and donor properties with respect to lithium halide. α-dextrins ensure the presence in the studied mixtures of the three active centers located within the α-dextrin helix: molecular iodine coordinated lithium halo genides and polypeptides, triiodide, and lithium halo genides. Using UV spectroscopy, the interaction of α-dextrin-LiCl(I)-I2-polypeptid with the AGA nucleotide triplet was investigated. Comparison of the quantum chemical calculations carried out for electronic transitions obtained for the structure that models the interaction of α-dextrin-LiCl(I)-I2-polypeptid with the nucleotide triplet indicates that the DNA nucleotides can displace polypeptide and form stable complexes with molecular iodine and lithium halo genides