Abstrait

Click chemistry: A novel tool in pharmaceutical research.

Ashish Arun Karle1*, Ashish Jain1, Mrs. Gangotri Yadav1, Bhushan Rane1, Sanket Mulgavkar2, Omkar Bagal2

The term click chemistry has been introduced with a goal to develop an expanding set of powerful, selective, and modular blocks that work reliably in both small- and large-scale applications includes reactions that are high yielding, wide in scope, create only by-products that can be removed without chromatography, are stereospecific, simple to perform, and can be conducted in easily removable or benign solvents. Click reactions usually join a biomolecule and a reporter molecule. Click chemistry is not limited to biological conditions. Click chemistry covers wide applications like drug design and discovery, bioconjugation, oligonucleotide and carbohydrate chemistry, peptide chemistry, radiochemistry, single chain nanoparticle construction, dendrimer synthesis, glycobiology, in synthesis of block copolymer, polymeric micelles etc. It also participates in modification of natural products and pharmaceuticals. It is a tool for drug target in several life threatening diseases or disorders like, Anticancer, antiviral, anti HIV, anti-tubercular or in diabetes mellitus. Oligonucleotides, proteins, polysaccharides, viruses and bacteria such as E. coli have all been successfully conjugated to various substances using this approach. Covalent and rapid linkage of two dissimilar components together under friendly, nontoxic conditions are properties that are completely complementary to the creation of novel agents for the development of both imaging and therapeutic products