Abstrait

A Rapids Immunodiagnostics Test for Active Tuberculosis

Anil Gupta

 Tuberculosis (TB) is a globally prevalent disease that is caused by the aerobic, gram-positive agent Mycobacterium tuberculosis. Despite the accessibility of broad-spectrum antibiotics which are very effective against M. tuberculosis, the social and financial burden of the patients with the disease continues to be huge, especially in the developing regions such as India and sub-Saharan Africa. This is mainly owing to limited laboratory infrastructure, treatment with the least sensitive diagnostics, and non-adherence to the standard therapeutic regimens. In less equipped countries like India, where most TB cases occur, diagnosis and management of such infections become difficult owing to unavailability of rapid, accurate, and cost-effective detection systems. The available tests are either time consuming, cumbersome, or very costly. Here, we introduced new antigen detection from patient blood samples using monoclonal antibodies generated against three novel recombinant antigens